Hepatitis E Virus (HEV) ORF2 Antigen Levels Differentiate Between Acute and Chronic HEV Infection

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Hepatitis E Virus (HEV) ORF2 Antigen Levels Differentiate Between Acute and Chronic HEV Infection.

BACKGROUND Hepatitis E virus (HEV) genotype 3 infections are frequent in Europe and North America, with acute and chronic courses described in the literature. HEV RNA detection by real-time polymerase chain reaction (PCR) is the gold standard for diagnosis. Recently, an anti-HEV antigen (Ag)-specific enzyme-linked immunosorbent assay (ELISA) directed against the HEV capsid became commercially a...

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Acute HEV Infection and AIH

NAGASAKI, F., UENO, Y., MANO, Y., IGARASHI, T., YAHAGI, K., NIITSUMA, H., OKAMOTO, H. and SHIMOSEGAWA, T. A Patient with Clinical Features of Acute Hepatitis E Viral Infection and Autoimmune Hepatitis. Tohoku J. Exp. Med., 2005, 206 (2), 173-179 ── Hepatitis E virus (HEV) is one of the major causative agents of acute hepatitis in many developing countries. Recent intensive examination has revea...

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Management of Hepatitis E Virus (HEV) Zoonotic Transmission: Protection of Rabbits against HEV Challenge following Immunization with HEV 239 Vaccine

Hepatitis E virus (HEV) constitutes a significant health burden worldwide, with an estimated approximately 33% of the world's population exposed to the pathogen. The recent licensed HEV 239 vaccine in China showed excellent protective efficacy against HEV of genotypes 1 and 4 in the general population and pregnant women. Because hepatitis E is a zoonosis, it is also necessary to ascertain wheth...

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Subcellular localization of hepatitis E virus (HEV) replicase.

Hepatitis E virus (HEV) is a hepatotropic virus with a single sense-strand RNA genome of approximately 7.2 kb in length. Details of the intracellular site of HEV replication can pave further understanding of HEV biology. In-frame fusion construct of functionally active replicase-enhanced green fluorescent protein (EGFP) gene was made in eukaryotic expression vector. The functionality of replica...

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ژورنال

عنوان ژورنال: Journal of Infectious Diseases

سال: 2016

ISSN: 0022-1899,1537-6613

DOI: 10.1093/infdis/jiw161